Smart Polymeric Nano-Constructs in Drug Delivery: Concept, Design and Therapeutic Applications provides a thorough discussion of the most state of the art material and polymer exploitations for the delivery of bioactive(s) as well as their current and clinical status. The book enables researchers to prepare a variety of smart drug delivery systems to investigate their properties as well as to discover their uses and applications. The novelty of this approach addresses an existing need of exhaustively understanding the potential of the materials including polymeric drug delivery systems that are smartly designed to deliver bioactive(s) into the body at targeted sites without showing side effects. The book is helpful for those in the health sector, specifically those developing nanomedicine using smart material-based nano-delivery systems. Polymers have unique co-operative properties that are not found with low-molecular-weight compounds along with their appealing physical and chemical properties, constituting the root of their success in drug delivery. Smart Polymeric Nano-Constructs in Drug Delivery: Concept, Design and Therapeutic Applications discusses smart and stimuli responsive polymers applicable in drug delivery, followed detailed information about various concepts and designing of polymeric novel drug delivery systems for treatment of various type of diseases, also discussing patents related to the field. The book helps readers to design and develop novel drug delivery systems based on smart materials for the effective delivery of bioactive that take advantage of recent advances in smart polymer-based strategies. It is useful to those in pharmaceutical sciences and related fields in developing new drug delivery systems.

Leprosy is a neuropathic disease caused by the M.laprae, which specially affect the nerves of the dermal tissue and multiply here. Conventional treatment is based on antibiotics and essentially Dapsone, which is the core drug for all leprosy treatment. Leprosy requires high doses of Dapsone for very long period of time, which in turn, is responsible for the side effect. Such prolonged therapy, with untoward side effects, is a major draw back. Thus it is desirable to make a dosage form, which could avoid most of the adverse effect of Dapsone, and preparing the liposome of the drug can do it. But only drug bearing liposomes don't have the targeting ability. To make liposomes targetable, liposomes are coated with the viral or bacterial docking proteins of bacterial or synthetic origin, which are simply the bacterial or viral proteins that make the attachment of bacteria/virus to the specific cell receptors for the fusion with cell membrane and causing invasion into the cell. In the case of leprosy a liposome based system could be developed and targeted to nerve endings where the bacterial load is high where they proliferate in tissue specific manner.